Abstract
Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Buddleja*
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Iridoids / chemistry
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Iridoids / isolation & purification
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Iridoids / pharmacology*
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Lipoxygenase / metabolism
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Lipoxygenase Inhibitors / chemistry
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Lipoxygenase Inhibitors / isolation & purification
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Lipoxygenase Inhibitors / pharmacology*
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Models, Molecular
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Structure-Activity Relationship
Substances
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Antioxidants
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Iridoids
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Lipoxygenase Inhibitors
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Plant Extracts
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Lipoxygenase